From the Guidelines
You should consult with your healthcare provider about persistent sexual side effects from Lurasidone (Latuda), as some antipsychotic medications can cause long-lasting changes to neurotransmitter systems or receptor sensitivity, leading to conditions like post-SSRI sexual dysfunction (PSSD) or similar conditions 1. Some antipsychotic medications like Lurasidone can cause sexual dysfunction by affecting dopamine and serotonin pathways in the brain, which regulate sexual function.
- The exact mechanisms of how Lurasidone affects sexual function are not fully understood, but it is thought to be related to its effects on dopamine and serotonin receptors in the brain.
- While most sexual side effects typically resolve within weeks to months after stopping medication, some people experience persistent sexual dysfunction.
- Your doctor might recommend strategies such as adjusting any current medications, considering treatments like bupropion which may help sexual function, or referring you to a sexual health specialist.
- They can also rule out other potential causes of sexual dysfunction like hormonal changes, other medications, psychological factors, or underlying health conditions that might have developed independently of your previous Lurasidone use 1. It is essential to discuss your symptoms with your healthcare provider to determine the best course of action and to rule out any underlying conditions that may be contributing to your persistent sexual side effects.
- A thorough evaluation of your medical history, current medications, and lifestyle habits may be necessary to identify potential causes of your symptoms.
- Your healthcare provider may also consider ordering laboratory tests or referring you to a specialist for further evaluation and treatment.
- In the meantime, it is crucial to prioritize your overall health and well-being by maintaining a healthy lifestyle, including a balanced diet, regular exercise, and stress management techniques.
From the Research
Possible Causes of Muted Orgasms
- Lurasidone, an antipsychotic medication, may have caused sexual dysfunction, including muted orgasms, as a side effect 2, 3.
- Although the study on lurasidone does not specifically mention muted orgasms, it does discuss the importance of inquiring about sexual dysfunction during antipsychotic therapy 2.
- Another study suggests that psychotropic drugs, including antipsychotics, can cause male sexual dysfunctions, such as ejaculatory dysfunction, which may be related to muted orgasms 3.
Persistence of Symptoms after Discontinuation
- A study on selective serotonin reuptake inhibitors (SSRIs) found that sexual dysfunctions, including anorgasmia and ejaculatory anhedonia, can persist even after discontinuation of the medication 4.
- This study suggests that some medications can cause long-term effects on the sexual response cycle, which may persist after discontinuation 4.
- Although this study is specific to SSRIs, it is possible that similar effects may occur with other psychotropic medications, including antipsychotics like lurasidone.
Treatment and Management
- A practical guide for sexual medicine providers suggests that treating delayed orgasm and anorgasmia can be challenging due to the lack of standardized FDA-approved pharmacotherapies 5.
- The guide recommends a multidisciplinary approach, including adjustment of offending medications and sex therapy, to manage these conditions 5.
- In the case of lurasidone, it may be necessary to consider alternative medications or treatments to manage sexual dysfunction, as well as to monitor for any potential cardiovascular effects 6, 3.