What is the appropriate use of papain (Papase) for pediatric patients?

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Last updated: May 22, 2025View editorial policy

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From the Research

Papase is not a recognized medication or treatment for children, and its use is not supported by recent high-quality evidence. If you're looking for a digestive enzyme supplement for children, there are other options available that have been studied and shown to be safe and effective. For example, bromelain, a complex natural mixture of sulfhydryl-containing proteolytic enzymes extracted from pineapple, has been used to treat various health problems and is considered a safe nutraceutical 1. However, there is no conclusive evidence to support the use of bromelain in children, and further studies are needed to better elucidate its mechanism of action and properties in various therapeutic areas.

Some key points to consider when looking for a digestive enzyme supplement for children include:

  • The type and source of the enzyme, as well as the dosage and potential interactions with other medications
  • The potential benefits and risks of using a particular enzyme supplement, including any known side effects or allergic reactions
  • The importance of consulting with a healthcare provider before giving any new supplement to a child, especially if they have a pre-existing medical condition or are taking other medications

In terms of specific enzyme supplements, papain, a cysteine protease found in papaya, has been shown to have region-specific effects on gastric motility and may be beneficial in treating functional gastrointestinal disorders 2. However, more research is needed to fully understand its effects and potential uses in children. Another option is a papain-based enzyme solution, which has been used to unclog enteral feeding tubes and may be safe and effective for this purpose 3.

It's also important to note that while some enzyme supplements may be safe and effective, others may not be, and it's always best to consult with a healthcare provider before giving any new supplement to a child. Additionally, it's essential to follow the recommended dosage and administration instructions for any supplement, and to monitor the child for any potential side effects or interactions.

References

Research

Current Uses of Bromelain in Children: A Narrative Review.

Children (Basel, Switzerland), 2024

Research

Pharmacokinetic and Pharmacological Aspects of a Papain-Based Enzyme Solution for Rescuing Clogged Enteral Feeding Tubes.

Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates, 2021

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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