What is the best course of action for a 63-year-old diabetic patient with a non-healing foot ulcer and suspected osteomyelitis?

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Last updated: May 22, 2025View editorial policy

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From the Guidelines

I strongly recommend continuing wound care with weekly debridement for this diabetic patient with a chronic non-healing wound on his right second toe, as the most recent and highest quality study suggests that consistent offloading and proper wound care are crucial for healing 1. The current plan to repeat the wound culture, order a CMP, obtain an X-ray of the right foot to rule out osteomyelitis, and request a podiatry consult is appropriate. The patient's history shows inconsistent wound care compliance since initially reporting the wound in November 2023 after self-treating for two years. The recent wound culture showing heavy Staphylococcus aureus growth necessitated systemic antibiotics, and according to the Infectious Diseases Society of America guidelines, antibiotic therapy is necessary for virtually all infected wounds, but it is often insufficient without appropriate wound care 1. For diabetic foot wounds, consistent offloading is crucial, so reinforcing the importance of wearing prescribed medical shoes at all times when weight-bearing is essential, as suggested by the IWGDF guidance on footwear and offloading interventions 1. The patient's diabetes complicates wound healing due to impaired circulation and immune response, making professional wound care necessary. Regular monitoring for infection signs, maintaining glycemic control, and ensuring proper nutrition will support healing. The podiatry consultation will provide specialized assessment and potentially more advanced treatment options if the wound continues to show poor healing progress. It is also important to consider the patient's overall health and potential comorbidities, as well as the risk of osteomyelitis, which can be difficult to diagnose and treat, as noted in the 2012 IDSA clinical practice guideline for the diagnosis and treatment of diabetic foot infections 1. Overall, a comprehensive approach to wound care, including consistent offloading, proper wound care, and management of underlying conditions, is essential for promoting healing and preventing complications in this patient.

From the Research

Wound Care and Management

  • The patient's wound care has been ongoing since September 2024, with weekly debridement, and has shown signs of infection with a heavy growth of Staphylococcus aureus 2.
  • The use of desiccation to treat Staphylococcus aureus biofilm-infected wounds has been studied, and it was found that desiccation via exposure to open air or honey leads to improved wound healing by decreasing bacterial burden and inflammation, and increasing granulation tissue formation 2.
  • Swab cultures can be used to identify potential pathogens in wound infections, but they should not be used to determine if a wound is acutely infected 3.

Infection Control and Treatment

  • The patient was treated with systemic antibiotics for the Staphylococcus aureus infection, and a repeat wound culture will be performed to assess the effectiveness of the treatment.
  • The study on limited success with open debridement and retention of components in the treatment of acute Staphylococcus aureus infections after total knee arthroplasty found that only one out of 13 patients infected with Staphylococcus aureus was successfully treated with debridement and component retention 4.
  • The importance of proper wound management, including dressings and bandages, in minimizing healing duration, reducing bioburden, and improving patient quality of life has been emphasized 5.

Future Directions

  • A consult with a podiatrist has been requested to further assess and manage the patient's wound.
  • The patient's wound care plan will continue to be monitored and adjusted as necessary to promote healing and prevent further complications.
  • The use of telemonitoring and defining patient expectations can help simplify wound care and improve patient outcomes, as suggested by the Wound Healing Foundation consensus 6.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

The use of desiccation to treat Staphylococcus aureus biofilm-infected wounds.

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 2016

Research

An update on wound management.

Australian prescriber, 2023

Research

Chronic wounds: Treatment consensus.

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 2022

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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