Differential Diagnosis for Globes Sensation in Retrosternal Area
- Single most likely diagnosis
- Gastroesophageal reflux disease (GERD): This condition is characterized by the backflow of stomach acid into the esophagus, which can cause a sensation of a lump or globus in the retrosternal area. The symptoms are often exacerbated by lying down or eating certain foods.
- Other Likely diagnoses
- Esophageal spasm: This condition involves abnormal muscle contractions of the esophagus, which can cause chest pain and a sensation of a lump in the throat or retrosternal area.
- Esophagitis: Inflammation of the esophagus, often caused by acid reflux, can lead to symptoms such as difficulty swallowing, chest pain, and a globus sensation.
- Anxiety or stress: High levels of anxiety or stress can cause muscle tension in the throat and chest, leading to a sensation of a lump or globus in the retrosternal area.
- Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
- Esophageal cancer: Although rare, esophageal cancer can cause a sensation of a lump or globus in the retrosternal area, especially if the tumor is located in the upper or middle part of the esophagus.
- Cardiac conditions (e.g., myocardial infarction, angina): Chest pain or discomfort can sometimes be referred to the retrosternal area and may be accompanied by a sensation of a lump or globus.
- Rare diagnoses
- Esophageal ring or web: A narrowing of the esophagus caused by a ring or web of tissue can lead to difficulty swallowing and a sensation of a lump in the retrosternal area.
- Zenker's diverticulum: A rare condition where a pouch forms in the upper part of the esophagus, which can cause symptoms such as difficulty swallowing, regurgitation of food, and a globus sensation.
- Thyroid enlargement or goiter: An enlarged thyroid gland can put pressure on the esophagus and trachea, leading to a sensation of a lump in the throat or retrosternal area.