From the Research
Ivermectin and rifaximin can generally be used together as there is no significant drug interaction between them. These medications work through different mechanisms and are prescribed for different conditions. Ivermectin is primarily an antiparasitic medication used to treat infections like strongyloidiasis and onchocerciasis, while rifaximin is an antibiotic that works in the intestines to treat conditions like traveler's diarrhea and irritable bowel syndrome with diarrhea. Both medications are minimally absorbed systemically when taken orally, which reduces the risk of interaction. Ivermectin is metabolized by the CYP3A4 enzyme system, while rifaximin has minimal effect on this system 1.
Some key points to consider when taking these medications together include:
- Ivermectin is typically dosed at 200 mcg/kg as a single dose for most parasitic infections
- Rifaximin is usually taken as 200 mg three times daily for traveler's diarrhea or 550 mg three times daily for IBS with diarrhea
- It is essential to follow the specific dosing instructions for each condition being treated
- Inform your healthcare provider about all medications you are taking to ensure safe use
It's also important to note that while ivermectin has been studied for various uses, including COVID-19 treatment and prevention 2, its primary use remains as an antiparasitic agent. Additionally, there have been reports of ivermectin-induced liver injury 3, highlighting the need for careful monitoring when using this medication. However, in the context of the interaction with rifaximin, the available evidence suggests that they can be used together without significant concern 1.