What is the cause of hematuria (presence of blood in urine) 2 days after nephrolithiasis (kidney stone) removal?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: May 24, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Guidelines

Pink-colored urine for 2 days after kidney stone removal is typically a normal and expected finding, likely due to minor bleeding from the procedure, as indicated by the presence of hematuria which can occur after urologic procedures 1. This condition is characterized by the presence of blood in the urine, which can be either microscopic or gross, with the latter being visible to the patient or physician. The American Urological Association defines microhematuria as three or more red blood cells per high power field on microscopic evaluation of urinary sediment 1. Given that the patient has recently undergone a kidney stone removal procedure, which is a known cause of hematuria, it is reasonable to attribute the pink-colored urine to this procedure. Key points to consider in this scenario include:

  • The color of the urine should gradually change from bright red or pink to lighter pink and then clear over the course of a few days to a week
  • If the patient experiences bright red urine with clots, severe pain, fever above 101°F, foul-smelling urine, or if the pink color persists beyond a week, they should contact their doctor immediately as these could indicate complications like infection or significant bleeding 1
  • During recovery, it's essential to drink plenty of fluids (8-10 glasses of water daily) to help flush the system, take prescribed pain medications as directed, and avoid strenuous activities for 1-2 weeks as recommended by the doctor. The patient's recent medical history of kidney stone removal is a crucial factor in assessing the cause of the hematuria, and according to the guidelines, patients with a suspected cause of microhematuria, including recent urologic procedure, are unlikely to gain any benefit from a complete imaging workup of microhematuria 1.

From the Research

Possible Causes of Pink Colored Urine

  • Blood in the urine (hematuria) can cause pink or red discoloration, which may occur after a kidney stone removal procedure 2
  • Infection or inflammation in the urinary tract can also lead to changes in urine color, although this is not directly related to pink colored urine 3
  • Certain medications, such as ciprofloxacin, can cause renal side effects, including crystalluria and crystal nephropathy, but this is not typically associated with pink colored urine 4, 5, 6

Post-Kidney Stone Removal Considerations

  • After a kidney stone removal procedure, patients may experience bleeding or hematuria, which can cause pink or red colored urine 2
  • It is essential to follow the doctor's instructions and attend follow-up appointments to monitor for any potential complications or infections 3
  • If patients experience any unusual symptoms, such as severe pain, fever, or changes in urine color, they should seek medical attention promptly 3

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Management of urinary tract infections associated with nephrolithiasis.

Current infectious disease reports, 2010

Research

Acute Pyelonephritis in Adults: Rapid Evidence Review.

American family physician, 2020

Research

Ciprofloxacin-induced crystal nephropathy.

Iranian journal of kidney diseases, 2014

Research

Ciprofloxacin for the management of urinary tract infection.

Women's health (London, England), 2006

Related Questions

What is the management for kidney stones and pyelonephritis with mildly hydronephrosis?
Can you perform a clinical analysis of the following diagnoses: complicated urinary tract infection (UTI) in treatment secondary to right nephrostomy, acute kidney injury (AKI) stage 1 according to Kidney Disease: Improving Global Outcomes (KDIGO), decompensated heart failure New York Heart Association (NYHA) class II, and lower limb ulcers with pyoderma gangrenosum?
What is the appropriate treatment for a 93-year-old patient weighing 114 pounds with a urinary tract infection caused by 100,000 CFU of ciprofloxacin-sensitive Enterococcus?
What is the duration of Cipro (ciprofloxacin) therapy for a urinary tract infection (UTI) in patients with impaired renal function?
What is the treatment plan for a patient with leukocyturia (White Blood Cell count 21-50), hematuria (Red Blood Cell count 21-30), bacteriuria (many bacteria), hemoglobinuria (trace blood), proteinuria (100 mg), and esterase-positive leukocytes, with imaging findings of mild left hydroureteronephrosis, a 3 mm ureterovesical junction (UVJ) stone, and urinary bladder wall thickening suggestive of cystitis?
What are the differential diagnoses (Ddx) for thrombocytopenia (low platelet count)?
A 54-year-old male presents with pharyngitis, nasal congestion, rhinorrhea, cough, myalgia, and fatigue, after taking Tylenol (acetaminophen), with possible fever and diaphoresis, but no nausea, vomiting, chest pain, or dyspnea?
What is the toxicity profile of Carboplatin (a chemotherapeutic agent)?
What are the medications for insomnia (sleep disorder)?
What is the treatment for squamous cell carcinoma with a single positive lymph node?
What is the significance of an absolute neutrophil count of 1180 cells/mm^3, indicating neutrophilia?

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.