From the Research
Tacrolimus ointment is a highly effective treatment for dyshidrotic eczema, and the recommended regimen is to apply tacrolimus 0.1% ointment twice daily to affected areas during active flares until resolution, then reduce to once daily for maintenance if needed, as supported by the most recent and highest quality study 1.
Treatment Regimen
The treatment regimen for dyshidrotic eczema using tacrolimus ointment involves:
- Applying a thin layer of tacrolimus 0.1% ointment to clean, dry skin
- Washing hands after application unless treating the hands themselves
- Using the ointment twice daily during active flares until resolution
- Reducing to once daily for maintenance if needed
- For severe cases, starting with twice daily application for 2-4 weeks, then tapering to twice weekly for prevention of recurrence
Mechanism of Action
Tacrolimus works as a calcineurin inhibitor that suppresses T-cell activation and inflammatory cytokine production, reducing the inflammatory response in eczema without causing skin atrophy like topical steroids 1.
Common Side Effects
Common side effects of tacrolimus ointment include temporary burning or stinging sensation upon application 1.
Optimal Results
For optimal results, combine tacrolimus ointment with good skin care practices, including:
- Regular moisturizing
- Avoiding triggers such as irritants and allergens
- If no improvement occurs after 2 weeks of consistent use, reassessment by a healthcare provider is recommended 2.
Evidence Support
The effectiveness of tacrolimus ointment for dyshidrotic eczema is supported by a Cochrane systematic review and network meta-analysis, which ranked tacrolimus 0.1% among the most effective treatments for improving patient-reported symptoms and clinician-reported signs 1.