From the Research
Expired Ativan (lorazepam) typically loses potency gradually rather than suddenly after its expiration date, with its effectiveness decreasing by approximately 5-10% per year past the expiration date, as supported by general knowledge of drug degradation 1. The rate of potency loss varies depending on storage conditions, with Ativan stored in cool, dry places away from light degrading more slowly than medication exposed to heat, humidity, or sunlight.
- The original potency, formulation (tablet vs. liquid), and packaging also affect degradation rates.
- For safety and efficacy reasons, it's strongly recommended to use only unexpired Ativan as prescribed.
- Expired medication may not provide the intended therapeutic effect for anxiety, insomnia, or seizure control. The chemical stability of benzodiazepines like Ativan changes over time as the active molecules break down, which is why potency decreases, as discussed in the context of benzodiazepine pharmacology 2. If you have expired Ativan, the best course of action is to properly dispose of it and obtain a new prescription rather than relying on medication with unpredictable effectiveness, considering the potential for underdosing or reduced efficacy as seen in clinical practice 3, 4. In clinical decision-making, it's essential to consider the limitations of evidence-based medicine and the importance of clinical reasoning in individualizing patient care, as emphasized in 1.