From the Research
There is no direct association between Patent Foramen Ovale (PFO) and Ehlers-Danlos Syndrome (EDS) established in the provided evidence. The connection between PFO and various clinical conditions such as migraines, coronary embolization, transient ischemic attacks, and stroke is well-documented 1. However, the provided studies do not specifically address the relationship between PFO and EDS. Some studies discuss the epidemiology, mechanisms, pathophysiology, diagnosis, screening, management, and effects on quality of life of PFO 2, 3, 4, but none of them mention EDS. One study investigates the risk of recurrence in stroke of determined etiology and PFO status, but it does not explore the link between PFO and EDS 5. Given the lack of direct evidence, it is essential to prioritize the management of PFO based on its own clinical indications, such as history of stroke or transient ischemic attack, rather than its potential association with EDS. For individuals with PFO, management typically involves:
- Regular cardiac monitoring
- Consideration of PFO closure if clinically indicated
- Antiplatelet therapy may be recommended in some cases. It is crucial for patients to discuss their specific condition and treatment options with their healthcare provider, as the management of PFO may vary depending on individual circumstances.