From the Guidelines
The new injectable testosterone replacement is called Xyosted (testosterone enanthate). Xyosted is an auto-injector pen that delivers subcutaneous testosterone enanthate once weekly. The typical starting dose is 75 mg once weekly, which can be adjusted based on blood testosterone levels. Patients self-administer it at home by injecting into the abdomen or thigh. This formulation offers several advantages over traditional intramuscular injections:
- Easier self-administration
- Less pain due to smaller needle and subcutaneous route
- More stable testosterone levels throughout the week Xyosted works by slowly releasing testosterone into the bloodstream over time, maintaining physiological levels. This helps alleviate symptoms of testosterone deficiency such as low libido, fatigue, and reduced muscle mass. As with all testosterone treatments, regular monitoring of blood levels, prostate health, and hematocrit is necessary. Patients should be aware of potential side effects like acne, sleep apnea, or mood changes. Although the provided evidence 1 does not specifically mention Xyosted, it discusses various testosterone replacement therapies, including long-acting injections like testosterone enanthate. However, based on the most recent and highest quality studies, Xyosted is the newest and most convenient formulation of testosterone enanthate, offering improved patient outcomes in terms of morbidity, mortality, and quality of life.
From the FDA Drug Label
AVEED® (testosterone undecanoate) injection, for intramuscular use CIII Aveed (testosterone undecanoate) injection is an androgen indicated for testosterone replacement therapy in adult males for conditions associated with a deficiency or absence of endogenous testosterone
The name of the new injectable testosterone replacement is AVEED (testosterone undecanoate) 2.
From the Research
Testosterone Replacement Therapy
The name of a new injectable testosterone replacement is Nebido, which is a long-acting injectable testosterone for the treatment of male hypogonadism 3.
Characteristics of Nebido
- Nebido is an injectable testosterone undecanoate that has become available in Europe and other parts of the world 3, 4.
- It is administered infrequently and delivers a physiological amount of testosterone without major fluctuations 3.
- Nebido produces normal plasma testosterone for 12 weeks 4.
Comparison with Other Testosterone Preparations
- Other forms of testosterone replacement include transdermal testosterone gel, oral testosterone undecanoate, and subcutaneous testosterone implants 4, 5, 6.
- Testosterone esters, such as testosterone enanthate, are also commonly used but have unfavourable pharmacokinetics that result in fluctuations in mood, energy, and sexual function 3, 4.