From the Guidelines
Combining nattokinase, grape seed extract, resveratrol, vitamin K, and vitamin D3 can potentially offer cardiovascular and overall health benefits, but should be done cautiously and under medical supervision, with careful consideration of potential interactions with blood-thinning medications, as evidenced by the study on warfarin therapy 1. A typical regimen might include:
- Nattokinase: 100-200 mg daily
- Grape seed extract: 100-300 mg daily
- Resveratrol: 250-500 mg daily
- Vitamin K2 (MK-7 form): 100-200 mcg daily
- Vitamin D3: 1000-5000 IU daily These supplements may work synergistically to support heart health, blood circulation, and bone strength. Nattokinase may help dissolve blood clots, grape seed extract and resveratrol offer antioxidant benefits, vitamin K2 aids in proper calcium utilization, and vitamin D3 supports overall immune function and bone health. However, be aware that nattokinase and vitamin K can interact with blood-thinning medications, as warfarin's anticoagulant effect can be influenced by vitamin K intake 1. Additionally, recent studies have shown that omega-3 fatty acids, such as those found in fish oil, can also have a beneficial effect on cardiovascular health, with a significant reduction in total MI and fatal MI 1. It is essential to consult with a healthcare provider before starting this combination, especially if you have any pre-existing health conditions or are taking other medications. Start with lower doses and gradually increase as tolerated. Monitor for any adverse reactions and adjust dosages as needed under professional guidance.
From the Research
Effects of Combining Nattokinase, Grape Seed Extract, Resveratrol, Vitamin K, and Vitamin D3
- There are no direct studies on the effects of combining nattokinase, grape seed extract, resveratrol, Vitamin K (Vit K), and Vitamin D3.
- However, studies have investigated the individual and combined effects of some of these components:
- Resveratrol and grape seed extract have been shown to have potential health benefits, including cardio protection, tumor suppression, and immune modulation 2, 3, 4, 5, 6.
- Resveratrol may lead to interactions with various cytochrome P450 (CYP) isoenzymes, especially when taken in high doses 2.
- Grape seed extract and resveratrol have been found to alleviate bisphenol-A-induced metabolic syndrome in rats, with improvements in blood pressure, serum lipid profile, and insulin signaling 3.
- Whole-grape products or specific combinations of grape constituents may provide synergistic interactions leading to improved efficacy in health promotion and disease management 4.
- Grape seed extract has been shown to have potential health benefits, including anti-inflammatory, anti-cancer, and cardiovascular protective effects 5, 6.
- The potential interactions between nattokinase, Vitamin K, and Vitamin D3 with the other components are not well understood and require further research.
- It is essential to consult with a healthcare professional before combining these supplements, as the potential interactions and effects on human health are not fully understood.