From the Research
Nattokinase does not appear to directly inhibit Interleukin-1 beta (IL-1β) and Interleukin-18 (IL-18) based on the provided evidence. The studies provided focus on the anti-inflammatory, anti-thrombotic, and fibrinolytic effects of nattokinase, but do not specifically mention its inhibition of IL-1β and IL-18. However, nattokinase has been shown to have anti-inflammatory effects by reducing pro-inflammatory cytokines such as TNF-α and IL-6 1, 2, 3. The typical recommended dose of nattokinase is 100-200 mg per day, taken on an empty stomach, and it is available as a dietary supplement in capsule or tablet form 4. It's essential to consult with a healthcare provider before starting any new supplement regimen, especially for those with pre-existing health conditions or those taking medications. The most recent and highest quality study, published in 2024, discusses the potential effects of nattokinase on mitigating the common complications of non-communicable diseases, such as inflammation and oxidative stress 2. While nattokinase shows promise in reducing inflammation, its specific effects on IL-1β and IL-18 are not well-established in the provided evidence. Key points to consider when using nattokinase include:
- Its blood-thinning properties, which require caution when taking blood thinners or before surgery
- Its potential to alleviate inflammation-related conditions and support overall cardiovascular health
- The importance of consulting with a healthcare provider before starting any new supplement regimen.