Can nattokinase help with bone marrow (myeloid tissue) inflammation?

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Last updated: February 21, 2025View editorial policy

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From the Research

Nattokinase is not specifically recommended for treating bone marrow inflammation, as there is currently insufficient scientific evidence to support its use for this purpose. Nattokinase is an enzyme derived from fermented soybeans (natto) that has some anti-inflammatory and blood-thinning properties. While it may have general anti-inflammatory effects in the body, its impact on bone marrow inflammation specifically has not been well-studied or established 1, 2, 3.

Key Points to Consider

  • The most recent and highest quality study on bone marrow inflammation treatment is the 2024 study on CK0801, an allogeneic T regulatory cell therapy product, which showed promise in treating bone marrow failure syndromes by interrupting the continuous loop of inflammation and restoring hematopoiesis 4.
  • Nattokinase has been shown to have anti-inflammatory effects in other contexts, such as vascular inflammation, by activating autophagy and inhibiting NLRP3 inflammasome and necroptosis 5.
  • However, its specific effects on bone marrow inflammation are not well-established, and conventional treatments prescribed by a hematologist are typically more appropriate.
  • If you're concerned about bone marrow inflammation, it's crucial to consult with a hematologist or oncologist for proper diagnosis and treatment.

Important Considerations

  • Nattokinase supplements are generally considered safe for most people, but they can interact with blood-thinning medications and may increase bleeding risk 3.
  • Always consult your doctor before starting any new supplement, especially if you have a blood disorder or are taking other medications.
  • The use of nattokinase as a treatment for bone marrow inflammation is not supported by current scientific evidence, and more research is needed to fully understand its potential effects in this context.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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