From the Research
Nattokinase can potentially affect ESR (erythrocyte sedimentation rate) test results by lowering ESR values due to its fibrinolytic, anti-inflammatory, and blood-thinning properties. Nattokinase is an enzyme derived from natto, a traditional Japanese fermented soybean food, which has been shown to have beneficial effects on cardiovascular health 1. The typical dosage of nattokinase supplements ranges from 100 to 200 mg per day, taken on an empty stomach, and has been demonstrated to be safe and effective in patients with vascular diseases 2. ESR is a non-specific marker of inflammation in the body, measuring how quickly red blood cells settle in a test tube over one hour. Nattokinase's anti-inflammatory properties may reduce the tendency of red blood cells to clump together, potentially leading to a lower ESR reading, as supported by a study that showed nattokinase decreased plasma levels of fibrinogen, factor VII, and factor VIII in human subjects 3. Some key points to consider when taking nattokinase supplements include:
- Informing your doctor about any nattokinase supplementation before having an ESR test, as it could affect the interpretation of your test results
- Discontinuing nattokinase at least two weeks before any scheduled surgery or dental procedure to reduce the risk of excessive bleeding
- Consulting with a healthcare provider before starting any new supplement regimen, especially if you have existing health conditions or are taking other medications. Overall, the current evidence suggests that nattokinase may have a positive effect on ESR values, but more research is needed to fully understand its effects on this specific marker of inflammation.