From the Research
Nattokinase supplements should be used with caution due to their potential to increase bleeding risk, particularly when combined with blood-thinning medications. The health effects of Nattokinase are not directly addressed in the provided evidence, but its potential to interact with other medications and increase bleeding risk is a concern. Nattokinase is an enzyme derived from fermented soybeans that has blood-thinning and clot-dissolving properties, which may offer cardiovascular benefits for some individuals. However, the lack of direct evidence on Nattokinase's health effects in the provided studies 1, 2, 3, 4, 5 limits our understanding of its potential benefits and risks. If you're considering taking Nattokinase supplements, it's essential to consult your doctor, especially if you're taking any blood thinners, to discuss potential interactions and adjust medication dosages as needed. For those not on blood thinners, typical Nattokinase dosages range from 100-200 mg per day, but it's crucial to start at the lower end and increase gradually while monitoring for any unusual bruising or bleeding. The blood-thinning effects of Nattokinase are due to its ability to break down fibrin, a protein involved in blood clotting, which complements but could dangerously amplify the effects of pharmaceutical anticoagulants, hence the need for caution when combining them. In general, it's essential to prioritize caution when using Nattokinase supplements, especially in the absence of direct evidence on their health effects, to minimize potential risks and maximize benefits. Some studies suggest that antioxidants like N-acetylcysteine (NAC) may have beneficial effects on human health 5, but the relationship between Nattokinase and NAC is not clear, and more research is needed to understand their potential interactions. Ultimately, the decision to use Nattokinase supplements should be made in consultation with a healthcare professional, taking into account individual health status, medication use, and potential risks and benefits.