From the Guidelines
Nattokinase may help reduce C-reactive protein (CRP) levels, potentially lowering inflammation in the body, although the current evidence does not directly support its relationship with CRP, and more research is needed to fully understand its effects. To implement this, consider the following steps:
- Choose a high-quality nattokinase supplement.
- Take 100-200 mg daily, preferably in the morning before eating.
- Continue for at least 2-3 months to assess effects on CRP levels.
- Combine with a healthy diet and regular exercise for best results. It's essential to note that while nattokinase shows promise, it should not replace prescribed medications. Those on blood thinners or with bleeding disorders should consult a healthcare provider before use, as nattokinase can enhance the effects of anticoagulants 1. Regular blood tests can help monitor CRP levels and adjust dosage if needed. Nattokinase works by breaking down fibrin, a protein involved in blood clotting and inflammation. By reducing fibrin buildup, it may improve blood flow and decrease overall inflammation, potentially leading to lower CRP levels. However, the relationship between nattokinase and CRP is not directly supported by the provided evidence, which focuses on the role of inflammation and CRP in cardiovascular disease, rather than the specific effects of nattokinase on CRP levels 1. Some studies suggest that CRP is a marker of inflammation and a predictor of cardiovascular events, and that reducing CRP levels may help lower the risk of cardiovascular disease 1. But the direct relationship between nattokinase and CRP remains unclear, and more research is needed to fully understand its effects. In the context of real-life clinical medicine, it is crucial to prioritize caution and consider the potential benefits and risks of using nattokinase to reduce CRP levels. Healthcare providers should consult with patients and carefully weigh the potential benefits against the potential risks before recommending nattokinase supplementation. Additionally, patients should be closely monitored for any adverse effects, and their CRP levels should be regularly checked to assess the effectiveness of the treatment. By taking a cautious and evidence-based approach, healthcare providers can help patients make informed decisions about using nattokinase to reduce CRP levels and potentially lower their risk of cardiovascular disease.
From the Research
Relationship between Nattokinase and C-Reactive Protein (CRP)
- There is no direct evidence in the provided studies that establishes a relationship between Nattokinase and C-Reactive Protein (CRP) [ 2, 3, 4, 5 ].
- However, a study on omega-3 fatty acids found that they can effectively mitigate high-sensitivity C-reactive protein (hs-CRP) biomarker of inflammation in acute myocardial infarction patients [ 6 ].
- Another study found that Nattokinase attenuates endothelial inflammation through the activation of SRF and THBS1, which could potentially have an indirect effect on CRP levels [ 4 ].
- The available evidence suggests that Nattokinase has anti-inflammatory properties, but its specific relationship with CRP is not well-established [ 2, 4 ].