From the Research
Increased urinary frequency with negative urine tests and normal creatinine and blood sugar levels could indicate overactive bladder syndrome, and I recommend keeping a bladder diary for 3-5 days, tracking fluid intake, urination frequency, and any associated symptoms, as well as considering medication like tolterodine 2mg twice daily, which has been shown to be effective and well-tolerated in patients with overactive bladder 1.
Possible Causes
- Overactive bladder syndrome
- Urinary tract infection (despite negative initial tests)
- Interstitial cystitis
- Prostate issues in men
Recommended Steps
- Keep a bladder diary for 3-5 days to track fluid intake, urination frequency, and associated symptoms
- Limit caffeine, alcohol, and artificial sweeteners that can irritate the bladder
- Try timed voiding (urinating every 2-3 hours rather than waiting until urgency occurs)
- Consider consulting a healthcare provider for further evaluation, including urodynamic testing or cystoscopy
Treatment Options
- Anticholinergics like tolterodine 2mg twice daily, which has been shown to be effective and well-tolerated in patients with overactive bladder 1
- Beta-3 agonists like mirabegron 25-50mg daily
- Pelvic floor exercises to improve bladder control
Rationale
The symptoms of increased urinary frequency with negative urine tests and normal creatinine and blood sugar levels suggest overactive bladder syndrome, which can be effectively managed with medication and lifestyle changes. Tolterodine has been shown to be a well-tolerated and effective treatment option for overactive bladder, with superior tolerability compared to oxybutynin 1. By keeping a bladder diary and trying timed voiding, patients can better understand their symptoms and develop strategies to manage them. If symptoms persist, further evaluation and treatment by a healthcare provider may be necessary.