From the Research
It is not recommended to take nattokinase, Angelica dahurica, and vitamin K together on the same day without consulting a healthcare professional first. Nattokinase is an enzyme that may have blood-thinning effects, while vitamin K plays a crucial role in blood clotting. Taking them together could potentially interfere with each other's actions and affect your blood's ability to clot properly. Angelica dahurica may also have blood-thinning properties, which could further complicate this combination, as suggested by its arginine kinase inhibitory activity 1.
Potential Risks and Interactions
The combination of these substances can affect blood coagulation in different ways. Nattokinase and Angelica dahurica may thin the blood, while vitamin K is essential for producing clotting factors. Combining them without proper guidance could potentially increase the risk of bleeding or clotting issues. Although nattokinase has been shown to be safe in high doses 2, its interaction with other substances like Angelica dahurica and vitamin K is not well understood.
Recommended Approach
If you need to take these supplements, it's best to space them out. For example, you might take nattokinase and Angelica dahurica at least 2 hours apart from vitamin K. However, the exact timing and dosage should be determined by a healthcare provider who is familiar with your medical history and current medications. This approach is supported by the fact that nattokinase has been studied for its potential application in biomedicine, including its production and purification 3, but its use in combination with other substances requires careful consideration.
Importance of Medical Supervision
Always inform your doctor about all supplements and medications you're taking to ensure safe and effective use. This is particularly important when combining substances that can affect blood coagulation, as the risk of adverse interactions can be significant. By consulting a healthcare professional, you can minimize the risks associated with taking nattokinase, Angelica dahurica, and vitamin K, and ensure that you are using these substances in a way that prioritizes your morbidity, mortality, and quality of life.