What is the treatment for heat stroke (hyperthermia)?

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Last updated: May 27, 2025View editorial policy

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From the Guidelines

Heat stroke treatment should prioritize immediate active cooling, with whole-body cool- to cold-water immersion for 15 minutes or until neurological symptoms resolve, as recommended by the 2024 American Heart Association and American Red Cross guidelines for first aid 1. When treating heat stroke, it is essential to move the individual from the hot environment, remove excess clothing, limit exertion, and provide cool liquids if the person is able to swallow, as stated in the guidelines 1. Key considerations for heat stroke treatment include:

  • Activating emergency services for people with heatstroke, characterized by altered mental status 1
  • Initiating immediate active cooling using whole-body cool- to cold-water immersion for 15 minutes or until neurological symptoms resolve, for both adults and children 1
  • Using alternative forms of active cooling, such as commercial ice packs, cold showers, ice sheets and towels, cooling vests and jackets, and evaporative, fanning, or a combination of techniques, when water immersion is not available 1
  • Measuring core temperature during active cooling, with a target core temperature of 39° C (102.2° F), for trained and willing first aid providers 1 It is crucial to prioritize these cooling measures to rapidly lower the body temperature and prevent organ damage, as heat stroke can be life-threatening due to high temperatures denaturing proteins and damaging cells throughout the body.

From the Research

Heat Stroke Treatment Overview

  • Heat stroke is a life-threatening condition that requires immediate treatment, with the primary objectives being rapid cooling and support of organ-system function 2.
  • The prognosis of heat stroke is directly related to the degree of hyperthermia and its duration, making rapid cooling the most important feature in treatment 3.

Cooling Methods

  • Immersion in an ice-water bath is considered the most effective cooling method, with evaporative cooling being a rapid and effective alternative 2, 4.
  • Evaporative plus convective cooling may be augmented by crushed ice or ice packs applied diffusely to the body, and chilled intravenous fluids may also supplement primary cooling 4.
  • Cold water immersion or convection evaporation method can be implemented based on the specific patient characteristic 5.

Treatment Protocols

  • Aggressive IV rehydration should be continued for the first 24 to 72 hours to prevent the development of rhabdomyolysis-induced acute renal failure, with the goal of maintaining a minimum urine output of 2 mL/kg/h 2.
  • Treatment of heat cramps consists of fluid and salt replacement (PO or IV) and rest in a cool environment, with IV magnesium sulphate being effective in relieving muscle cramping in severe cases 2.
  • Preventive strategies include early recognition by health workers, socialization to vulnerable groups, and adequate acclimatization 5.

Recommendations

  • Ice-water immersion has been shown to be highly effective in exertional heat stroke, with a zero fatality rate in large case series of younger, fit patients 4.
  • Evaporative plus convective cooling is often promoted for older patients with nonexertional heat stroke 4.
  • Protocols based on evaporative cooling are advocated as the most efficient, based on military and civilian experiences worldwide 6.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

[Treatment of heat stroke].

Nihon rinsho. Japanese journal of clinical medicine, 2012

Research

Heat stroke : a review of cooling methods.

Sports medicine (Auckland, N.Z.), 2004

Research

Cooling Methods in Heat Stroke.

The Journal of emergency medicine, 2016

Research

Diagnosis and Management of Heatstroke.

Acta medica Indonesiana, 2020

Research

Heat-stroke: a review of rapid cooling techniques.

Intensive & critical care nursing, 1995

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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