From the Research
Descovy (emtricitabine/tenofovir alafenamide) is not known to directly cause acne as a common side effect, and if you're taking Descovy for HIV prevention (PrEP) or HIV treatment and experiencing acne, the acne is likely unrelated to the medication. According to the most recent and highest quality study, 1, acne affects approximately 9% of people worldwide and is the most common skin condition in the USA, with first-line agents including topical retinoids, azelaic acid, benzoyl peroxide, and combinations of these agents.
Some key points to consider when treating acne include:
- Topical retinoids are indicated for acne of any severity and for maintenance therapy 2
- Systemic and topical antibiotics should be used only in combination with benzoyl peroxide and retinoids and for a maximum of 12 weeks 2
- Isotretinoin is used for severe, recalcitrant acne, but requires registration with the U.S. Food and Drug Administration-mandated risk management program, iPledge, due to the risk of teratogenicity 2
If you've noticed acne developing or worsening after starting Descovy, continue taking your medication as prescribed and consult your healthcare provider about acne treatment options. They may recommend over-the-counter products containing benzoyl peroxide or salicylic acid, or prescribe treatments like topical retinoids or antibiotics if needed. Your provider can help determine if your acne is related to Descovy or has other causes such as hormonal changes, stress, or other factors. Never stop taking Descovy without medical guidance, as maintaining your HIV treatment or prevention regimen is critically important for your health.
In terms of treatment, the combination of clindamycin 1%-benzoyl peroxide 5% gel is efficacious and well-tolerated, and may be used in conjunction with topical retinoids to create a more targeted and complete treatment strategy 3. Additionally, newer approaches to the treatment of acne vulgaris, such as topical dapsone, taurine bromamine, and resveratrol, may also be considered 4. However, it is essential to consult with a healthcare provider to determine the best course of treatment for individual cases of acne.