From the Guidelines
A uric acid level of 4.10 mg/dL is considered normal and healthy. Normal uric acid ranges are typically between 3.5-7.2 mg/dL for men and 2.5-6.0 mg/dL for women, so your value falls well within these normal parameters [ 1 ]. No treatment or intervention is needed for this level. Uric acid is a waste product formed when the body breaks down purines, which are found in certain foods and are also made naturally by the body. When uric acid levels become too high (a condition called hyperuricemia), it can lead to gout or kidney stones [ 1 ]. Your current level indicates your body is effectively processing and eliminating uric acid. To maintain healthy levels, continue with a balanced diet, stay well-hydrated, limit alcohol consumption, and maintain a healthy weight. Some key points to consider:
- Hyperuricemia is variably defined as serum urate greater than either 6.8 or 7.0 mg/dL [ 1 ]
- Gout is a disorder that manifests as a spectrum of clinical and pathologic features built on a foundation of an excess body burden of uric acid [ 1 ]
- The American College of Rheumatology (ACR) guidelines for management of gout emphasize safety, and quality of therapy, and reflect best practice [ 1 ] If you have a history of gout or kidney stones despite normal uric acid levels, you should still follow any specific dietary or medication recommendations from your healthcare provider.
From the FDA Drug Label
The upper limit of normal is about 7 mg/dL for men and postmenopausal women and 6 mg/dL for premenopausal women. A uric acid level of 4.10 mg/dL is considered normal and ok 2.
From the Research
Uric Acid Levels
- A uric acid level of 4.10 mg/dL is considered to be within the normal range for most adults 3, 4, 5, 6, 7.
- Normal uric acid levels typically range from 3.5 to 7.2 mg/dL for men and 2.6 to 6.0 mg/dL for women, although these ranges can vary slightly depending on the laboratory and measurement techniques used.
Comparison of Uric Acid Reduction
- Studies have compared the efficacy of febuxostat and allopurinol in reducing uric acid levels in patients with chronic kidney disease (CKD) and hyperuricemia 3, 4, 5, 6, 7.
- Febuxostat has been shown to be more effective than allopurinol in reducing serum uric acid levels in some studies 4, 5, while other studies have found that allopurinol is more effective in retarding CKD progression 6.
- The choice of urate-lowering therapy (ULT) depends on various factors, including the patient's kidney function, presence of comorbidities, and potential side effects of the medications.
Renal Outcomes
- The effects of febuxostat and allopurinol on renal outcomes, such as estimated glomerular filtration rate (eGFR) decline and end-stage renal disease, have been evaluated in several studies 3, 4, 5, 6, 7.
- Some studies have found that febuxostat may have a protective effect on the kidneys, while others have reported that allopurinol is more effective in slowing CKD progression 6.
- Further research is needed to fully understand the renal outcomes associated with febuxostat and allopurinol in patients with CKD and hyperuricemia.