What are the differential diagnoses for chest pain (thoracic pain)?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: May 28, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for Chest Pain

The differential diagnosis for chest pain is extensive and can be categorized into several groups. Here's a breakdown of the possible causes:

  • Single Most Likely Diagnosis
    • Gastroesophageal Reflux Disease (GERD): This is often the most common cause of chest pain, especially if the pain is related to eating or worsens with lying down. GERD can cause symptoms similar to cardiac conditions, making it a crucial consideration.
  • Other Likely Diagnoses
    • Musculoskeletal Pain: Strains or inflammation of the muscles and joints in the chest wall can cause significant pain. This is often related to physical activity or trauma.
    • Asthma or Chronic Obstructive Pulmonary Disease (COPD): Respiratory conditions can cause chest pain, especially if there's associated wheezing, coughing, or shortness of breath.
    • Pneumonia or Pulmonary Embolism: Although less common, these conditions can present with chest pain and are important to consider, especially in patients with risk factors or systemic symptoms like fever.
  • Do Not Miss Diagnoses
    • Myocardial Infarction (MI): Although not the most common cause, MI is a medical emergency that requires immediate attention. It's crucial to consider this diagnosis, especially in patients with risk factors like hypertension, diabetes, or a family history of heart disease.
    • Aortic Dissection: This is a life-threatening condition where the aorta tears, causing severe, tearing chest pain. It's essential to consider this diagnosis in patients with high blood pressure or a history of aortic aneurysm.
    • Pulmonary Embolism: While mentioned earlier, pulmonary embolism is a critical diagnosis to consider due to its high mortality rate if left untreated.
  • Rare Diagnoses
    • Pericarditis: Inflammation of the pericardium, the sac surrounding the heart, can cause chest pain. This condition is often associated with a pericardial friction rub.
    • Esophageal Spasm or Rupture: These conditions are less common but can cause severe chest pain. Esophageal rupture is a medical emergency requiring immediate surgical intervention.
    • Pneumothorax: A collapsed lung can cause sudden, severe chest pain, especially if it's a spontaneous pneumothorax in a young, healthy individual.

Each of these diagnoses has distinct characteristics and risk factors that can help guide the diagnostic process. A thorough history, physical examination, and appropriate diagnostic tests are essential for determining the underlying cause of chest pain.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.