What is the cause of a viral rash on the hands and feet, also known as Hand, Foot, and Mouth Disease (HFMD)?

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Differential Diagnosis for Viral Rash on Hands and Feet

  • Single most likely diagnosis
    • Hand, Foot, and Mouth Disease (HFMD): This is the most common diagnosis for a viral rash on the hands and feet, particularly in children. It is caused by viruses such as coxsackievirus A or enterovirus 71, and is characterized by a distinctive rash on the palms and soles, along with fever and oral ulcers.
  • Other Likely diagnoses
    • Measles: Although less common due to vaccination, measles can cause a rash that starts on the face and spreads to the hands and feet. It is accompanied by fever, cough, and conjunctivitis.
    • Rubella: Similar to measles, rubella (German measles) can cause a rash that spreads to the hands and feet, along with fever and lymphadenopathy.
    • Enterovirus infections: Besides HFMD, other enteroviruses can cause rashes on the hands and feet, often accompanied by fever and systemic symptoms.
  • Do Not Miss diagnoses
    • Meningococcemia: This is a life-threatening infection caused by Neisseria meningitidis, which can cause a rash on the hands and feet, along with fever, shock, and meningitis. Early recognition and treatment are crucial.
    • Rocky Mountain Spotted Fever: This tick-borne illness can cause a rash on the hands and feet, along with fever, headache, and abdominal pain. It requires prompt antibiotic treatment to prevent serious complications.
  • Rare diagnoses
    • Kawasaki Disease: This rare condition can cause a rash on the hands and feet, along with fever, lymphadenopathy, and conjunctivitis. It is an important diagnosis to consider, as it can lead to cardiac complications if left untreated.
    • Erythema multiforme: This is a rare skin condition that can cause a rash on the hands and feet, often triggered by viral infections or medications. It can be associated with systemic symptoms and requires prompt treatment to prevent complications.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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