From the Guidelines
A metallic taste in the mouth can be caused by several factors, including zinc deficiency, as indicated by a study published in Advances in Nutrition 1. Common causes of metallic taste include certain medications, dental problems, respiratory infections, pregnancy, vitamin deficiencies, and exposure to certain chemicals or metals. Medical conditions that may cause a metallic taste include acid reflux, diabetes, kidney or liver disorders, nervous system disorders like Bell's palsy, and hormonal imbalances. The sensation occurs when taste receptors on the tongue detect metal ions or when the brain misinterprets signals from damaged taste buds. If you experience a persistent metallic taste, it's advisable to consult a healthcare provider, especially if it's accompanied by other symptoms, as it could indicate an underlying condition requiring treatment. Maintaining good oral hygiene and staying hydrated may help alleviate the symptom in some cases. Additionally, a study published in Clinical Gastroenterology and Hepatology 1 highlights the importance of considering esophageal dysfunction in patients with autoimmune diseases, which may also contribute to metallic taste. However, the most recent and highest quality study on the topic of metallic taste is not directly provided in the given evidence, but zinc deficiency is a known cause of impaired sense of taste, as reported in the 2017 study 1. Other potential causes of metallic taste, such as certain medications or exposure to chemicals, are not directly supported by the provided evidence. Therefore, it is essential to consult a healthcare provider to determine the underlying cause of metallic taste and develop an appropriate treatment plan. In terms of morbidity, mortality, and quality of life, addressing the underlying cause of metallic taste is crucial to prevent potential complications and improve patient outcomes. For example, if the cause is a vitamin deficiency, supplementation may be necessary to prevent long-term damage. If the cause is a medication, alternative treatments may be explored to minimize side effects. Overall, a comprehensive approach to diagnosing and treating metallic taste is necessary to optimize patient care and improve quality of life.
From the FDA Drug Label
Special Senses: Tinnitus, taste perversion Triple therapy: The most frequently reported adverse events for patients who received triple therapy (amoxicillin/clarithromycin/ lansoprazole) were diarrhea (7%), headache (6%), and taste perversion (5%) Dual therapy:The most frequently reported adverse events for patients who received double therapy amoxicillin/lansoprazole were diarrhea (8%) and headache (7%). The metallic taste cause is taste perversion, which is a reported adverse reaction in patients taking omeprazole 2 and amoxicillin 3 3.
From the Research
Metallic Taste Causes
Some medications and medical conditions can cause a metallic taste in the mouth.
- Proton pump inhibitors (PPIs) are known to have various potential adverse effects 4
- However, metallic taste is not explicitly mentioned as a potential adverse effect of PPIs in the provided study 4
- The study focuses on other potential adverse effects of PPIs, such as nutritional deficiencies, rebound acid hypersecretion, and increased risk of certain infections and fractures 4
- There is no direct evidence in the provided study to suggest that PPIs cause a metallic taste 4