What is the ICD-10 (International Classification of Diseases, 10th Revision) code for Sickle Cell Disease?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: May 29, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Research

The ICD-10 code for sickle cell disease is D57, which encompasses several specific subtypes based on the exact presentation and genetic variant. For sickle cell anemia (Hb-SS disease), the specific code is D57.1. Other common variants include D57.0 for sickle cell anemia with crisis, D57.2 for double heterozygous sickling disorders (like Hb-SC or Hb-SD), and D57.3 for sickle cell trait (Hb-AS) 1. When documenting sickle cell disease, it's essential to specify the exact type and whether there are any acute complications present, as this affects the coding. For example, if a patient presents with sickle cell crisis with acute chest syndrome, the code D57.01 would be used. The specificity in coding is necessary because different sickle cell variants have different clinical courses, complications, and treatment approaches.

Key Considerations for Coding Sickle Cell Disease

  • The code D57 is used for sickle cell disease, with more specific codes for different variants and complications.
  • Healthcare providers should select the most specific code available based on laboratory confirmation of the hemoglobin type and the current clinical presentation 2.
  • Accurate coding is crucial for tracking the disease, managing patient care, and conducting research 3.
  • The use of standardized codes can help reduce heterogeneity and improve reproducibility in research studies 3.

Importance of Accurate Coding

Accurate coding of sickle cell disease is vital for ensuring that patients receive appropriate care and for tracking the disease's progression. It also enables healthcare providers to identify potential complications and develop effective treatment plans. Furthermore, accurate coding is essential for research purposes, as it allows for the collection of reliable data on the disease's prevalence, incidence, and outcomes 4, 5.

Coding Variants and Complications

The ICD-10 code D57 encompasses several specific subtypes of sickle cell disease, including:

  • D57.0: Sickle cell anemia with crisis
  • D57.1: Sickle cell anemia (Hb-SS disease)
  • D57.2: Double heterozygous sickling disorders (like Hb-SC or Hb-SD)
  • D57.3: Sickle cell trait (Hb-AS)
  • D57.01: Sickle cell crisis with acute chest syndrome

Healthcare providers should be familiar with these codes and use them accurately to ensure that patients receive appropriate care and that research studies are conducted effectively 1, 3.

References

Research

[Sickle Cell Disease in Newborns in Germany: Analysis of the AOK Health Insurance Data].

Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)), 2019

Research

Sickle cell disease.

Nature reviews. Disease primers, 2018

Research

Sickle Cell Disease.

Annals of internal medicine, 2021

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.