What is the cause of sudden onset shoulder pain without trauma, accompanied by arm weakness?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: May 29, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for Abrupt Shoulder Pain with No Trauma and Arm Weakness

  • Single most likely diagnosis
    • Rotator cuff strain or tendinitis: This is a common condition that can cause sudden shoulder pain and arm weakness, especially if the rotator cuff is inflamed or strained.
  • Other Likely diagnoses
    • Brachial neuritis (neuralgic amyotrophy): This condition is characterized by sudden onset of shoulder pain and arm weakness, often without any trauma.
    • Thoracic outlet syndrome: Compression of the nerves and blood vessels in the thoracic outlet can cause shoulder pain and arm weakness.
    • Cervical radiculopathy: Herniated discs or other cervical spine issues can cause radiating pain and weakness in the arm.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Pulmonary embolism: Although less common, a pulmonary embolism can cause sudden shoulder pain and arm weakness due to referred pain.
    • Aortic dissection: A tear in the aorta can cause sudden, severe pain that may radiate to the shoulder and arm.
    • Spinal cord infarction or compression: Any condition that compromises the spinal cord, such as a tumor or infection, can cause sudden arm weakness and shoulder pain.
  • Rare diagnoses
    • Pancoast tumor: A rare type of lung cancer that can cause shoulder pain and arm weakness due to compression of the nerves and blood vessels.
    • Amyotrophic lateral sclerosis (ALS): A progressive neurological disease that can cause arm weakness, although it is typically a more gradual onset.
    • Poliomyelitis: A rare viral infection that can cause arm weakness, although it is typically associated with a more systemic illness.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.