From the Guidelines
To rejuvenate healthy cells, focus on a comprehensive lifestyle approach that includes proper nutrition, regular exercise, adequate sleep, stress management, and targeted supplementation, as well as emerging strategies like tissue engineering and cell therapies. Eat a diet rich in antioxidants from colorful fruits and vegetables, omega-3 fatty acids from fatty fish, and polyphenols from berries, dark chocolate, and green tea 1. Aim for 150 minutes of moderate exercise weekly, including both aerobic and resistance training. Prioritize 7-9 hours of quality sleep nightly and practice stress reduction techniques like meditation or deep breathing for 10-15 minutes daily. Stay hydrated with 2-3 liters of water daily. Consider supplements like CoQ10 (100-200mg daily), NAD+ precursors such as nicotinamide riboside (250-500mg daily), and resveratrol (250-500mg daily) 1. Intermittent fasting, such as restricting eating to an 8-10 hour window, may activate cellular autophagy—the process where cells remove damaged components.
Key Considerations
- Tissue engineering strategies combined with cell therapies show promise for cardiac repair in ischaemic heart disease and heart failure 1
- The use of biomaterials, such as hydrogels, can provide a biomolecular and spatial environment conductive to cell survival, proliferation, and vascularization 1
- Exosomes and microvesicles with biomaterials may mediate paracrine stimulation of pro-angiogenesis pathways, alterations of macrophage phenotype, and anti-fibrotic effects 1
- Emerging fields like bioelectronics and immunoengineering may leverage the precision over immunotherapy and unlock the potential of chemical synthesis and chemical biology for advanced materials 1
Future Directions
- The development of precise, directed standardized protocols for cardiomyocytes subtype specification and functional maturation is crucial for the success of tissue engineering strategies 1
- The use of living units as sensors and processors to create stimuli-responsive, shape-changing, and adaptive materials could herald new advances for major challenges in biomedicine and sustainability 1
- Further innovations can leverage the precision over immunotherapy, enabling the creation of living materials that can be manipulated by cells 1
From the Research
Rejuvenating Healthy Cells
To rejuvenate healthy cells, several strategies can be employed, including:
- Physical activity: Regular exercise has been shown to have numerous health benefits, including reducing the risk of chronic diseases and improving overall health status 2, 3
- Vitamin D3 supplementation: Studies have found that vitamin D3 supplementation can help reduce telomere attrition, which can contribute to cellular aging 4
- Cellular reprogramming: This involves giving aged cells more youthful characteristics through various techniques, such as epigenetic regulation 5
- Removal of senescence cells: Senescence cells can contribute to aging and removing them can help promote cellular rejuvenation 5
- Metabolic manipulation: This involves manipulating cellular metabolism to promote rejuvenation, such as through dietary restriction 5
- Immune rejuvenation: This involves promoting immune function to help remove damaged or aged cells 5
Lifestyle Interventions
Lifestyle interventions can also play a crucial role in rejuvenating healthy cells, including:
- Regular physical exercise: This can help improve vascular health and reduce the risk of chronic diseases 2, 3, 6
- Body weight management: Maintaining a healthy weight can help reduce the risk of chronic diseases and promote overall health 6
- Healthy dietary patterns: Eating a healthy diet can help promote cellular rejuvenation and reduce the risk of chronic diseases 6
- Stress management: Chronic stress can contribute to aging and managing stress can help promote rejuvenation 6
- Adequate sleep patterns: Getting enough sleep is essential for overall health and can help promote cellular rejuvenation 6