From the Research
I strongly advise against taking acetazolamide with coca leaves due to potential harmful interactions that could lead to unpredictable cardiovascular effects, electrolyte imbalances, and excessive dehydration. The combination of acetazolamide, a carbonic anhydrase inhibitor used to treat altitude sickness, glaucoma, and certain seizure disorders, with coca leaves, which contain cocaine alkaloids that have stimulant effects, is not recommended. According to a recent study 1, acetazolamide is effective in preventing acute mountain sickness, but its use with other substances, especially stimulants like coca leaves, is not well-studied and may lead to adverse effects. Some key points to consider include:
- Acetazolamide alters the body's pH balance, while coca leaves can increase heart rate and blood pressure, potentially leading to unpredictable cardiovascular effects.
- Both substances can affect the body's electrolyte balance, potentially leading to dangerous imbalances.
- The diuretic effect of acetazolamide combined with the stimulant properties of coca leaves might cause excessive dehydration, particularly problematic at high altitudes where acetazolamide is commonly used. If you're considering using acetazolamide for altitude sickness prevention, it's recommended to stick to the prescribed medication alone, typically 500-750mg/day 1, starting 1-2 days before ascent and continuing for 2-3 days at high altitude, and avoid combining it with coca leaves or other stimulants. It's also important to note that the evidence for the use of acetazolamide with other substances is limited, and more research is needed to fully understand the potential risks and benefits of such combinations 2. In general, it's best to exercise caution when using any medication, especially in combination with other substances, and to consult with a healthcare professional before making any decisions.