From the Research
Hydroxychloroquine (Doloquine) is not recommended for treating recurrent miscarriage in most cases, as there is insufficient scientific evidence supporting its effectiveness for this condition in women without specific autoimmune disorders 1. The most recent and highest quality study, published in 2021, emphasizes the importance of individualized care and evidence-based interventions for recurrent miscarriage, but does not mention hydroxychloroquine as a recommended treatment 1.
Key Considerations
- Recurrent miscarriage is a complex condition with various potential causes, including chromosomal abnormalities, uterine anomalies, hormonal imbalances, and blood clotting disorders 2, 3, 4.
- Comprehensive testing and targeted treatments based on identified issues are essential for managing recurrent miscarriage 1.
- Evidence-based interventions for recurrent miscarriage may include progesterone supplementation, low-dose aspirin and heparin for confirmed clotting disorders, or lifestyle modifications 1.
Treatment Approach
- The typical approach for recurrent miscarriage involves comprehensive testing for potential causes, followed by targeted treatments based on identified issues 1.
- Hydroxychloroquine may be prescribed for pregnant women with antiphospholipid syndrome or lupus, but it is not a standard treatment for unexplained recurrent pregnancy loss 5.
- Medications should not be used during pregnancy without clear evidence of benefit and safety, and hydroxychloroquine carries potential risks and side effects 1.
Recommendations
- Women experiencing recurrent miscarriages should consult with a reproductive endocrinologist or maternal-fetal medicine specialist for appropriate evaluation and personalized treatment recommendations 1.
- A graded model of care, including online health-care advice and support, care in a nurse or midwifery-led clinic, and care in a medical consultant-led clinic, may be effective in managing recurrent miscarriage 1.