Differential Diagnosis for Night Sweats

• Single most likely diagnosis
  • Tuberculosis (TB): Night sweats are a classic symptom of TB, especially in its active form. The body's immune response to the infection can cause an increase in body temperature, leading to sweating at night.
• Other Likely diagnoses
  • Menopause: Hormonal changes during menopause can lead to hot flashes and night sweats in many women.
  • Anxiety and stress: High levels of stress and anxiety can cause an increase in body temperature and lead to night sweats.
  • Hypoglycemia: Low blood sugar levels, especially during sleep, can cause sweating, including night sweats.
  • Hyperthyroidism: An overactive thyroid gland can lead to an increase in metabolism, causing excessive sweating, including at night.
• Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
  • Lymphoma: Night sweats can be a symptom of lymphoma, a type of cancer that affects the immune system.
  • HIV/AIDS: Night sweats can be an early symptom of HIV infection, and it's essential to diagnose and treat the condition promptly.
  • Endocarditis: Infectious endocarditis, an infection of the heart valves, can cause night sweats, and delayed diagnosis can be fatal.
• Rare diagnoses
  • Pheochromocytoma: A rare tumor of the adrenal gland that can cause excessive sweating, including night sweats, due to the release of catecholamines.
  • Neurological disorders: Certain neurological conditions, such as autonomic dysfunction or peripheral neuropathy, can cause abnormal sweating patterns, including night sweats.
  • Medication side effects: Some medications, such as antidepressants or blood pressure medications, can cause night sweats as a side effect.