Differential Diagnosis for Newborn with Sleeping and Feeding Difficulties, Sneezing, Sweating, Tachypnea, Vomiting, and Diarrhea

• Single Most Likely Diagnosis
  • Neonatal Abstinence Syndrome (NAS): This condition occurs in newborns exposed to opioids or other substances in utero, leading to withdrawal symptoms after birth, which can include irritability, feeding difficulties, sneezing, sweating, tachypnea, vomiting, and diarrhea.
• Other Likely Diagnoses
  • Sepsis: Newborns with sepsis can present with non-specific symptoms such as feeding difficulties, vomiting, diarrhea, tachypnea, and sweating due to the body's systemic inflammatory response.
  • Congenital Infections (e.g., TORCH infections): Infections like toxoplasmosis, rubella, cytomegalovirus, and herpes simplex can cause a range of symptoms in newborns, including feeding difficulties, respiratory distress, and gastrointestinal symptoms.
  • Hypoglycemia: Low blood sugar in newborns can lead to symptoms such as jitteriness, sweating, tachypnea, and feeding difficulties.
• Do Not Miss Diagnoses
  • Congenital Heart Disease: While less likely to present with the exact combination of symptoms listed, congenital heart disease can lead to feeding difficulties, sweating, and tachypnea due to heart failure or decreased cardiac output.
  • Intestinal Obstruction: Conditions like pyloric stenosis or intestinal atresia can cause vomiting and feeding difficulties, and if not recognized promptly, can lead to severe dehydration and electrolyte imbalances.
• Rare Diagnoses
  • Congenital Adrenal Hyperplasia: This group of genetic disorders can lead to adrenal insufficiency, causing symptoms such as vomiting, diarrhea, and hypoglycemia in newborns.
  • Neurological Disorders (e.g., Spinal Muscular Atrophy): Certain neurological conditions can present with feeding difficulties, respiratory distress, and other non-specific symptoms in the newborn period.