Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: June 3, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for Newborn with Sleeping and Feeding Difficulties, Vomiting, and Diarrhea

  • Single Most Likely Diagnosis
    • Gastroesophageal reflux disease (GERD): This condition is common in newborns and can cause vomiting, feeding difficulties, and sleeping problems due to discomfort and pain associated with reflux.
  • Other Likely Diagnoses
    • Infectious gastroenteritis: Viral or bacterial infections can lead to vomiting, diarrhea, and subsequent feeding difficulties and sleep disturbances in newborns.
    • Lactose intolerance or cow's milk protein allergy: These conditions can cause gastrointestinal symptoms such as vomiting and diarrhea, leading to feeding difficulties and sleep issues.
    • Overfeeding or underfeeding: Improper feeding techniques or volumes can lead to vomiting, diarrhea, and feeding difficulties, affecting the newborn's sleep.
  • Do Not Miss Diagnoses
    • Congenital intestinal obstruction (e.g., pyloric stenosis, intestinal atresia): These conditions require prompt surgical intervention and can present with vomiting and feeding difficulties.
    • Hirschsprung's disease: A congenital condition characterized by the absence of ganglion cells in the colon, leading to severe constipation or intestinal obstruction, which can cause vomiting and feeding issues.
    • Inborn errors of metabolism (e.g., galactosemia): Certain metabolic disorders can cause vomiting, diarrhea, and feeding difficulties, and it is crucial to diagnose them early to initiate appropriate management.
    • Necrotizing enterocolitis: A serious condition that can occur in newborns, especially premature infants, characterized by inflammation and necrosis of the bowel, which can present with vomiting, diarrhea, and feeding difficulties.
  • Rare Diagnoses
    • Congenital infections (e.g., congenital CMV, toxoplasmosis): These infections can cause a range of symptoms, including gastrointestinal issues, in newborns.
    • Food protein-induced enterocolitis syndrome (FPIES): A rare condition characterized by inflammation of the colon and small intestine in response to certain food proteins, leading to vomiting, diarrhea, and feeding difficulties.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.