Differential Diagnosis for Newborn with Sleeping and Feeding Difficulties, Vomiting, Diarrhea, Sweating, and Tachypnea

• Single Most Likely Diagnosis
  • Congenital adrenal hyperplasia or other metabolic disorders: These conditions can lead to an imbalance in electrolytes and fluids, causing vomiting, diarrhea, and other symptoms. The presence of sweating and tachypnea may indicate a stress response or an underlying infection.
• Other Likely Diagnoses
  • Sepsis or neonatal infection: Newborns are susceptible to infections, which can cause a range of symptoms including feeding difficulties, vomiting, diarrhea, and respiratory distress.
  • Gastroesophageal reflux disease (GERD): This condition can cause vomiting and feeding difficulties, and may lead to sweating and tachypnea due to discomfort or pain.
  • Hypoglycemia: Low blood sugar can cause sweating, tachypnea, and feeding difficulties, and may be associated with vomiting and diarrhea.
• Do Not Miss Diagnoses
  • Congenital heart disease: Although less likely, congenital heart disease can cause feeding difficulties, sweating, and tachypnea due to decreased cardiac output or increased energy expenditure.
  • Intestinal obstruction: Conditions such as pyloric stenosis or intestinal atresia can cause vomiting, diarrhea, and feeding difficulties, and may lead to sweating and tachypnea due to pain or distress.
  • Neonatal abstinence syndrome: Newborns exposed to substances in utero can experience withdrawal symptoms, including vomiting, diarrhea, sweating, and tachypnea.
• Rare Diagnoses
  • Mitochondrial disorders: These conditions can cause a range of symptoms, including feeding difficulties, vomiting, diarrhea, and respiratory distress, due to impaired energy production.
  • Congenital neurodegenerative disorders: Certain conditions, such as congenital neuropathies or myopathies, can cause feeding difficulties, sweating, and tachypnea due to impaired muscle function or autonomic dysfunction.