From the Research
Yes, bone marrow inflammation can potentially cause elevated ACE (Angiotensin Converting Enzyme) levels, as supported by the most recent study in 2024 1. ACE is produced by various cells in the body, including those in the bone marrow. When there's inflammation in the bone marrow, it can lead to increased production and release of ACE into the bloodstream, resulting in higher than normal ACE levels. This elevation in ACE levels due to bone marrow inflammation is most commonly associated with conditions like sarcoidosis, which can affect multiple organs including the bone marrow. However, other inflammatory conditions affecting the bone marrow could potentially cause elevated ACE levels as well, such as multiple myeloma, as shown in a study from 2012 2. Some key points to consider:
- Elevated ACE levels can be indicative of bone marrow inflammation, but are not specific to this condition alone, and can be elevated in various other conditions, such as liver disease, diabetes, and certain types of cancer.
- The relationship between ACE levels and bone marrow inflammation is complex, and may involve the activation of the renin-angiotensin system in the bone marrow microenvironment, as suggested by a study from 2012 2.
- Further testing, such as a bone marrow biopsy, may be necessary for a definitive diagnosis if bone marrow inflammation is suspected based on elevated ACE levels and other symptoms.
- Treatment would then be directed at the underlying cause of the inflammation, and may involve the use of ACE inhibitors, as shown in a study from 2021 3 to reduce cardiac and vascular inflammation.