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Last updated: June 3, 2025View editorial policy

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Differential Diagnosis for Unilateral Lumbar Pain on Percussion

  • Single most likely diagnosis
    • Pyelonephritis or kidney infection: This condition often presents with unilateral flank or lumbar pain, which can be exacerbated by percussion due to the inflammation of the kidney.
  • Other Likely diagnoses
    • Musculoskeletal strain: Strain in the lumbar muscles or ligaments can cause localized pain that worsens with movement or percussion.
    • Nephrolithiasis (kidney stones): While kidney stones can cause severe, colicky pain, they might also present with more constant pain that is exacerbated by percussion, especially if the stone is causing an obstruction.
    • Lumbar disc herniation: A herniated disc can cause localized pain in the lumbar region, which might be worsened by percussion due to the pressure on the surrounding nerves.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Renal cell carcinoma or other kidney tumors: Although less common, tumors of the kidney can cause persistent pain and might be exacerbated by percussion.
    • Pneumonia or lung abscess: In rare cases, lower lobe pneumonia or a lung abscess can refer pain to the lumbar region, which could be worsened by percussion due to the involvement of the diaphragm or pleura.
    • Aortic aneurysm or dissection: An expanding aortic aneurysm or a dissection can cause severe back pain, which might be unilateral and could potentially worsen with percussion, although this is less typical.
  • Rare diagnoses
    • Osteomyelitis of the spine: Infection of the vertebral bodies can cause localized pain that worsens with percussion.
    • Spinal epidural abscess: A collection of pus in the epidural space surrounding the spinal cord can cause severe back pain, which might be exacerbated by percussion.
    • Retroperitoneal fibrosis: A rare condition characterized by the proliferation of fibrous tissue in the retroperitoneum, which can encase and obstruct structures like the ureters, leading to pain that could potentially worsen with percussion.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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