From the Guidelines
Myrbetriq 25 mg can cause significant side effects, including hypertension, UTIs, headache, and nasopharyngitis, and is contraindicated in patients with severe uncontrolled hypertension. When used for treating overactive bladder, patients should be aware of these potential side effects before starting therapy. According to a recent study published in the European Urology journal in 2023 1, mirabegron, the active ingredient in Myrbetriq, is well tolerated in the elderly and in patients with multiple comorbidities. However, the most frequent adverse events (AEs) associated with mirabegron are:
- Hypertension
- UTIs
- Headache
- Nasopharyngitis It is essential to monitor blood pressure regularly, particularly in hypertensive patients, as Myrbetriq can cause significant increases in blood pressure 1. Patients with severe uncontrolled hypertension should not use this medication. The study also notes that long-term data on the efficacy and safety of mirabegron in men of any age with LUTS are not available 1.
Some key precautions to consider when using Myrbetriq 25 mg include:
- Regular blood pressure monitoring
- Caution in patients with kidney or liver impairment
- Potential drug interactions with other medications that affect blood pressure or are metabolized through the CYP2D6 pathway
- Consultation with healthcare providers before use in pregnant women, nursing mothers, and children, as safety in these populations is not well established 1.
Overall, while Myrbetriq 25 mg can be an effective treatment for overactive bladder, patients should be aware of the potential side effects and take necessary precautions to minimize risks.
From the FDA Drug Label
What are the possible side effects of mirabegron extended-release tablets? Mirabegron extended-release tablets may cause serious side effects, including: • increased blood pressure. • inability to empty your bladder (urinary retention) • angioedema Adults with Overactive Bladder The most common side effects of mirabegron extended-release tablets include: • high blood pressure • pain or swelling of the nose or throat (nasopharyngitis) • urinary tract infection • headache
The potential side effects of Myrbetriq (mirabegron) for treating overactive bladder include:
- Serious side effects: increased blood pressure, inability to empty the bladder (urinary retention), and angioedema
- Common side effects in adults with Overactive Bladder: high blood pressure, pain or swelling of the nose or throat (nasopharyngitis), urinary tract infection, and headache 2
From the Research
Myrbetriq 25 mg Side Effects
The potential side effects of Myrbetriq (mirabegron) 25 mg for treating overactive bladder include:
- Hypertension 3, 4, 5, 6
- Nasopharyngitis 3, 4
- Urinary tract infection 3, 4, 6
- Headache 4
- Constipation 4, 7
- Upper respiratory tract infection 4
- Arthralgia 4
- Diarrhea 4
- Tachycardia 4
- Abdominal pain 4
- Fatigue 4
Precautions
When taking Myrbetriq 25 mg, precautions should be taken to monitor:
- Blood pressure, as mirabegron may increase the risk of hypertension 3, 4, 5
- Urinary tract infections, as they are a common adverse event associated with mirabegron 3, 4, 6
- Dry mouth, although the incidence is similar to placebo and lower than antimuscarinic agents 3, 7, 5
Efficacy
Myrbetriq 25 mg has been shown to be effective in treating overactive bladder symptoms, including: