From the Guidelines
Mybetriq (mirabegron) can cause several side effects, including hypertension, UTIs, headache, and nasopharyngitis, as reported in a 2023 meta-analysis of eight randomised controlled trials 1. When considering the management of non-neurogenic male lower urinary tract symptoms (MLUTS) with Mybetriq, it is essential to weigh the benefits against the potential risks. The most frequent adverse events (AEs) associated with mirabegron include:
- Hypertension
- Urinary tract infections (UTIs)
- Headache
- Nasopharyngitis These side effects are well-documented in the literature, with a recent study published in the European Urology journal highlighting the safety profile of mirabegron 1. It is crucial to note that mirabegron is contraindicated in patients with severe uncontrolled hypertension, and its use should be carefully considered in patients with multiple comorbidities 1. Regular blood pressure monitoring is recommended, especially when starting this medication, to minimize the risk of adverse events. Patients should be aware of the potential side effects and discuss any concerns with their healthcare provider before starting treatment with Mybetriq.
From the FDA Drug Label
The most commonly reported adverse reactions (greater than 2% of mirabegron patients and greater than placebo) were hypertension, nasopharyngitis, urinary tract infection, and headache The most common side effects of mirabegron extended-release tablets include: • high blood pressure • pain or swelling of the nose or throat (nasopharyngitis) • urinary tract infection • headache Mirabegron extended-release tablets may cause serious side effects, including: • increased blood pressure. • inability to empty your bladder (urinary retention) • angioedema
Common side effects of Mybetriq (mirabegron) include:
- Hypertension
- Nasopharyngitis
- Urinary tract infection
- Headache Serious side effects of Mybetriq (mirabegron) include:
- Increased blood pressure
- Urinary retention
- Angioedema 2 2
From the Research
Mybetriq Side Effects
Mybetriq, also known as mirabegron, is a medication used to treat overactive bladder (OAB) symptoms. The common side effects of mirabegron include:
- Hypertension
- Nasopharyngitis
- Urinary tract infection
- Headache
- Constipation
- Upper respiratory tract infection
- Arthralgia
- Diarrhea
- Tachycardia
- Abdominal pain
- Fatigue 3, 4, 5, 6
Comparison with Other Treatments
Mirabegron has been compared to other treatments for OAB, such as tolterodine, in terms of efficacy and safety. Studies have shown that mirabegron is effective in reducing incontinence episodes, micturitions, and urgency episodes, and improving voided volume 3, 4, 6. Additionally, mirabegron has been found to have a good safety profile, with a lower risk of overall treatment-emergent adverse events compared to tolterodine 6.
Specific Side Effects
Some studies have reported specific side effects associated with mirabegron, including:
- Dry mouth, which is less common compared to antimuscarinic agents 3
- Hypertension, which is a common side effect 3, 4, 5, 6
- Cardiac arrhythmia, which has been reported in some studies 6
- Urinary tract infection, which is a common side effect 3, 4, 5, 6
Long-Term Safety
The long-term safety of mirabegron has been evaluated in several studies, which have shown that it is well-tolerated and effective in reducing OAB symptoms over a period of 12 months 3, 7.