What is the recommended treatment for mastitis in pregnancy?

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Last updated: June 3, 2025View editorial policy

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From the Research

The recommended treatment for mastitis in pregnancy involves a 1- to 2-day trial of conservative measures, such as nonsteroidal anti-inflammatory drugs, ice application, feeding the infant directly from the breast, and minimizing pumping, before considering narrow-spectrum antibiotics to cover common skin flora, as most cases are caused by inflammation and not a true infection 1.

Key Considerations

  • Diagnosis is made clinically based on symptoms such as fever, malaise, focal breast tenderness, and overlying skin erythema or hyperpigmentation without the need for laboratory tests or imaging 1.
  • Obtaining milk cultures should be considered to guide antibiotic therapy, and ultrasonography should be performed to identify abscesses in immuno-compromised patients or those with worsening or recurrent symptoms 1.
  • Factors that increase the risk of mastitis include overstimulation of milk production and tissue trauma from aggressive breast massage; therefore, frequent overfeeding, excessive pumping to empty the breast, heat application, and breast massage are no longer recommended because they may worsen the condition 1.

Treatment Approach

  • Conservative measures are often sufficient for treatment, and antibiotics may be prescribed if there is no improvement in symptoms 1.
  • Narrow-spectrum antibiotics, such as those effective against Staphylococcus and Streptococcus, may be used to cover common skin flora 1.
  • Most patients can be treated as outpatients with oral antibiotics; however, if the condition worsens or there is a concern for sepsis, intravenous antibiotics and hospital admission may be required 1.

Prevention

  • The best prevention is a proper lactation technique, including a good infant latch, and encouraging physiologic breastfeeding rather than pumping, if possible 1.

References

Research

Mastitis: Rapid Evidence Review.

American family physician, 2024

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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