What is the right pyriform sinus?

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From the Guidelines

The right pyriform sinus is an anatomical structure located in the throat, specifically at the lower part of the pharynx where it joins the esophagus. It is one of two pear-shaped recesses (hence the name "pyriform," meaning pear-shaped) that lie on either side of the laryngeal inlet, with the right pyriform sinus being on the right side. This structure serves as a channel that directs food and liquid away from the airway and toward the esophagus during swallowing. The pyriform sinuses are lined with mucous membrane and are bounded medially by the aryepiglottic fold and laterally by the thyroid cartilage and thyrohyoid membrane. These sinuses are clinically significant as they can trap foreign bodies, harbor infections, or develop cancerous lesions. During endoscopic examinations of the throat, the right pyriform sinus is an important landmark that otolaryngologists and gastroenterologists evaluate for abnormalities such as inflammation, masses, or structural changes that might indicate disease 1.

Some key points to consider about the right pyriform sinus include:

  • Its location in the throat and its role in swallowing
  • Its boundaries and the structures that surround it
  • Its potential to harbor infections or develop cancerous lesions
  • Its significance as a landmark during endoscopic examinations of the throat

It's worth noting that while the provided evidence discusses various topics related to sinusitis and the paranasal sinuses, the specific question about the right pyriform sinus is most directly addressed by considering its anatomical location and clinical significance 1.

From the Research

Definition and Location

  • The right pyriform sinus is a part of the laryngeal structure, specifically located on the right side of the larynx.
  • It is one of the two pyriform sinuses, the other being the left pyriform sinus, which are recesses on either side of the laryngeal entrance [ 2 ].

Clinical Significance

  • The right pyriform sinus can be a site for abnormalities, such as fistulae, which are rare on the right side [ 2 ].
  • Branchial cleft cysts and pyriform sinus fistulae must be considered in the diagnosis of cervical abscesses on either side of the neck [ 2 ].

Treatment and Management

  • Treatment options for conditions affecting the right pyriform sinus, such as fistulae, include surgical excision and cauterization [ 2 ].
  • Chemocauterization with 40% trichloroacetic acid has been used successfully to treat right-sided pyriform sinus fistulae [ 2 ].

Related Conditions and Therapies

  • While the provided studies do not directly link the right pyriform sinus to cancer treatment, they discuss various therapies for cancer, including radiation therapy [ 3 ], multimodal therapy for esophageal cancer [ 4 ], and new approaches such as stem cell therapy and targeted therapy [ 5, 6 ].

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Cancer and radiation therapy: current advances and future directions.

International journal of medical sciences, 2012

Research

Recent advances in cancer therapy: an overview.

Current pharmaceutical design, 2010

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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