From the Research
It is generally safe to take magnesium supplements with fluoxetine, but it is essential to consult your healthcare provider first, as individual factors may affect this recommendation. The most recent and highest quality study, 1, published in 2022, investigated the effect of magnesium supplements in patients with major depressive disorder under selective serotonin reuptake inhibitor (SSRI) treatment, including fluoxetine. This study found that administration of magnesium supplements for at least 6 weeks may improve depression symptoms and can be considered as a potential adjunct treatment option for patients with major depressive disorder who are under SSRI treatment.
When taking magnesium supplements with fluoxetine, it is recommended to:
- Separate the magnesium supplement from fluoxetine by at least 2 hours to prevent potential absorption issues
- Start with a lower magnesium dose (around 200-300mg daily) and monitor for side effects like diarrhea or stomach upset
- Choose magnesium supplements in forms that are better absorbed and gentler on the stomach, such as magnesium citrate and glycinate, rather than magnesium oxide
Some people take magnesium to help with side effects of SSRIs like fluoxetine, particularly for sleep issues or muscle tension, as magnesium plays important roles in muscle function and nervous system regulation. However, magnesium is not a replacement for prescribed medication, and adding any supplement to the regimen should be discussed with a doctor. It is also important to note that while magnesium may have benefits, it is crucial to prioritize the prescribed medication and consult with a healthcare provider before making any changes to the treatment plan, as seen in studies such as 2, 3, 4, and 5.