From the Research
The starting dose for vaginal estradiol tablets is typically 10 micrograms (mcg) inserted vaginally once daily for the first two weeks, followed by a maintenance dose of 10 mcg twice weekly. This dosage is based on the study by 1, which evaluated the endometrial safety of ultra-low-dose estradiol vaginal tablets and found that the incidence of endometrial hyperplasia and carcinoma was low, supporting the safety of this dosage. The medication is inserted deep into the vagina using the provided applicator, and it is used to treat vaginal atrophy symptoms such as dryness, burning, itching, and painful intercourse that occur due to decreased estrogen levels, particularly during menopause. Some key points to consider when using vaginal estradiol tablets include:
- The low-dose local therapy delivers estrogen directly to vaginal tissues where it's needed, minimizing systemic absorption while effectively relieving symptoms.
- Most women begin experiencing symptom improvement within 1-2 weeks, though full benefits may take 4-12 weeks.
- It's essential to use the medication regularly as prescribed, even after symptoms improve, to maintain the therapeutic effect.
- If a dose is missed, it should be used as soon as remembered, but skipped if it's almost time for the next dose, as supported by studies such as 2. Overall, the use of vaginal estradiol tablets at the recommended dosage has been shown to be effective and safe for the treatment of vaginal atrophy symptoms, as demonstrated by studies including 1 and 2.