From the Research
Niacinamide is a highly effective treatment for hyperpigmentation, with studies showing significant improvements in reducing the appearance of hyperpigmented spots and enhancing skin lightness. The most recent and highest quality study, 1, published in 2021, provides a comprehensive review of the mechanistic basis and clinical evidence for the applications of nicotinamide (niacinamide) to control skin aging and pigmentation. This study suggests that nicotinamide restores cellular NAD+ pool and mitochondrial energetics, attenuates oxidative stress and inflammatory response, enhances extracellular matrix and skin barrier, and inhibits the pigmentation process in the skin.
Key Findings
- Niacinamide works by inhibiting the transfer of melanin to skin cells, reducing inflammation, and providing antioxidant protection 2, 1
- Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials 3, 1
- Niacinamide is particularly helpful for post-inflammatory hyperpigmentation, melasma, and sun damage 2, 4
- For enhanced results, combine niacinamide with other brightening ingredients like vitamin C, alpha arbutin, or retinoids 5
Recommendations
- Use products containing 4-5% niacinamide concentration, applied twice daily for at least 8-12 weeks before expecting visible improvement
- Combine niacinamide with other brightening ingredients for enhanced results
- Apply sunscreen (SPF 30+) daily to prevent further hyperpigmentation and skin damage
- Niacinamide is generally well-tolerated even by sensitive skin types, with minimal side effects compared to more aggressive treatments like hydroquinone, making it suitable for long-term use in your skincare routine 2, 1