Is topical Niacinamide (Vitamin B3) effective for treating skin aging?

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Last updated: June 10, 2025View editorial policy

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From the Research

Topical niacinamide is a highly effective treatment for skin aging, with the most recent and highest quality study 1 demonstrating its ability to reduce fine lines, wrinkles, and hyperpigmentation, while improving skin elasticity and firmness. The use of topical niacinamide for skin aging is supported by multiple studies, including a 2024 review 1 that highlights its mechanisms of action, including increasing ceramide and fatty acid levels in the skin, antioxidant properties, and stimulation of collagen production. Key benefits of topical niacinamide include:

  • Reduction in fine lines and wrinkles
  • Improvement in skin hyperpigmentation
  • Enhancement of skin elasticity and firmness
  • Antioxidant properties that protect against environmental damage
  • Inhibition of the transfer of melanin to skin cells, which helps fade dark spots
  • Suitable for all skin types, including sensitive skin
  • Can be safely combined with other active ingredients like retinoids and vitamin C for enhanced anti-aging benefits. According to the study 1, niacinamide has been shown to be well-tolerated and safe for use in cosmetics, with no convincing evidence of specific molecular targets for controlling skin aging and pigmentation. The recommended concentration of topical niacinamide is typically between 2-10% in serums and moisturizers, applied once or twice daily to clean skin before heavier moisturizers and sunscreen, with noticeable improvements seen after at least 8-12 weeks of use 2, 3.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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