What are the symptoms of Staphylococcal (Staph) skin infections?

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From the Guidelines

Staphylococcal skin infections typically present with redness, swelling, warmth, and tenderness in the affected area, and the most common symptom is the appearance of a painful, red bump or boil that may be filled with pus, as noted in the 2018 WSES/SIS-E consensus conference 1.

Symptoms of Staphylococcal Skin Infections

The symptoms of Staphylococcal skin infections can vary depending on the type and severity of the infection. Some common symptoms include:

  • Redness and swelling in the affected area
  • Warmth and tenderness to the touch
  • Painful, red bumps or boils that may be filled with pus
  • Skin that appears red and inflamed around small blisters or honey-colored crusts, characteristic of impetigo
  • Fever, chills, and fatigue in more severe cases
  • Expanding areas of redness and swelling, characteristic of cellulitis

Classification of Skin and Soft-Tissue Infections

The 2018 WSES/SIS-E consensus conference recommends classifying skin and soft-tissue infections based on the necrotizing or non-necrotizing character of the infection, the anatomical extension, the characteristics of the infection (purulent or not purulent), and the clinical condition of the patient 1. This classification system can help guide treatment decisions and ensure that patients receive appropriate care.

Importance of Seeking Medical Attention

It is essential to seek medical attention if symptoms worsen despite home care, or if there is rapid spreading of redness, fever, or other signs of infection 1. Staph bacteria can thrive on the skin and in mucous membranes, and infections can occur when these bacteria enter through breaks in the skin, leading to localized inflammation and pus formation as the body's immune system responds to the infection. Prompt medical attention can help prevent the spread of infection and reduce the risk of complications.

From the Research

Symptoms of Staphylococcal Skin Infections

The symptoms of Staphylococcal skin infections can vary depending on the severity and type of infection. Some common symptoms include:

  • Primary pyodermas, which are superficial, localized, and sometimes self-limiting infections 2
  • Cellulitis, which is an infection of the soft tissues 2, 3
  • Pyomyositis, which is an infection of the muscle 2
  • Surgical site infections, which can occur after surgery 2
  • Infections in intravenous drug users, which can occur at the site of injection 2
  • Peeling skin, which can occur at sites of external pressure, such as peripheral intravenous sites or under dressings 4
  • Sepsis, which can cause symptoms such as temperature instability, apnea, and bradycardia episodes 4
  • Localized pustules, boils, tears, or crusts, which can be signs of a Staphylococcal skin infection 4, 3
  • Cardinal signs of inflammatory response, such as fever, rapid progression of lesions, and bullae 5

Severity of Infections

The severity of Staphylococcal skin infections can range from mild to severe, and the choice of treatment depends on the severity of the infection. Some infections may be self-limiting, while others may require antibiotic treatment or even hospitalization 2, 3, 5.

Types of Infections

There are different types of Staphylococcal skin infections, including:

  • Methicillin-susceptible Staphylococcus aureus (MSSA) infections, which can cause diseases ranging from localized skin infections to serious invasive infections 4
  • Methicillin-resistant Staphylococcus aureus (MRSA) infections, which can be more difficult to treat and may require specialized antibiotic therapy 2, 3
  • Staphylococcal scalded skin syndrome (SSSS), which is a rare but severe skin presentation of MSSA infections 4

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Staphylococcal Skin and Soft Tissue Infections.

Infectious disease clinics of North America, 2021

Research

Staphylococcal Scalded Skin Syndrome, Identification, and Wound Care: A Case Report Series.

Advances in neonatal care : official journal of the National Association of Neonatal Nurses, 2022

Research

Bacterial skin and soft tissue infections in adults: A review of their epidemiology, pathogenesis, diagnosis, treatment and site of care.

The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale, 2008

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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