From the Research
Men with higher estradiol levels generally have a lower risk of cardiovascular mortality, as supported by the most recent and highest quality study available. Research suggests that estradiol, the primary form of estrogen, plays a protective role in the cardiovascular system for men, particularly as they age 1. Optimal estradiol levels in men typically range between 20-30 pg/mL, though individual variations exist. This protective effect occurs because estradiol helps maintain healthy blood vessel function, reduces inflammation, improves lipid profiles, and supports proper endothelial function. Estradiol promotes vasodilation, helping to maintain healthy blood pressure and reducing strain on the heart. It also has anti-inflammatory properties that may reduce atherosclerotic plaque formation. However, it's essential to note that both extremely low and extremely high estradiol levels can be problematic for men. Very high levels may increase thrombotic risk, while very low levels are associated with increased cardiovascular risk, as seen in a study where low levels of estradiol were associated with elevated risk of CVD mortality 1.
Some studies have suggested that high estradiol levels may be associated with increased mortality in older men, particularly from non-cardiovascular causes 2. However, the most recent and highest quality study available, published in 2022, found that low levels of estradiol were associated with elevated risk of CVD mortality in young and middle-aged men 1. Another study published in 2023 found that hyperestrogenia was an independent predictor for the presence of arterial hypertension in young and middle-aged men, but did not find a significant difference in the total risk of cardiovascular diseases calculated with the SCORE scale 3.
In terms of the relationship between estradiol levels and cardiovascular risk, a study published in 2006 found that higher estradiol levels were associated with lower risk for CVD in older men, but not in younger men 4. However, the most recent study available, published in 2022, found that low levels of estradiol were associated with elevated risk of CVD mortality in young and middle-aged men, suggesting that the relationship between estradiol levels and cardiovascular risk may be more complex than previously thought 1.
Men concerned about their estradiol levels should consult healthcare providers for appropriate testing and potential interventions, which might include lifestyle modifications or, in some cases, hormonal management under medical supervision. Key points to consider include:
- Estradiol levels can impact cardiovascular risk in men
- Optimal estradiol levels typically range between 20-30 pg/mL
- Both low and high estradiol levels can be problematic for men
- Estradiol helps maintain healthy blood vessel function and reduces inflammation
- Men should consult healthcare providers for testing and potential interventions if concerned about their estradiol levels.