From the Guidelines
The recommended dose of Daflon (diosmin) for treating hemorrhoids is typically 1000 mg daily, as suggested by the most recent and highest quality study available 1.
Dosage and Administration
- The dose of 1000 mg daily is often recommended for the first 4 days, followed by 500 mg daily for the next 3 days.
- For long-term management or prevention of recurrence, 500-1000 mg daily is often recommended.
- Daflon should be taken with meals to improve absorption.
Mechanism of Action and Efficacy
- Daflon works by strengthening vein walls, improving venous tone, and reducing inflammation in the affected area.
- It typically takes 5-7 days to notice symptom improvement, though complete resolution may take longer.
- The use of flavonoids, such as Daflon, has been shown to relieve symptoms of hemorrhoids, as suggested by a weak recommendation based on moderate quality evidence 1.
Safety and Tolerability
- Daflon is generally well-tolerated, but some patients may experience mild digestive discomfort.
- It can be used alongside other hemorrhoid treatments like topical creams, sitz baths, and increased fiber intake.
- If symptoms don't improve after 7 days of treatment or worsen at any point, medical consultation is advised.
- Daflon is considered safe for most adults but should be used during pregnancy or breastfeeding only under medical supervision.
Additional Considerations
- The role of flavonoids and phlebotonics in the treatment of hemorrhoids has been extensively studied, with major meta-analyses showing a statistically significant beneficial effect for the outcomes of pruritus, bleeding, and overall symptom improvement 1.
- However, the definition of "symptomatic" hemorrhoids used in these studies is unclear, and more research is needed to determine the optimal treatment approach.
From the Research
Daflon Dose for Hemorrhoids
- The recommended dose of Daflon (diosmin) for treating hemorrhoids varies across studies, but a common dosage is 2 tablets per day, in two divided doses, for a period of 4 weeks 2, 3.
- Another study used a dosage of 3 tablets bid for the first four days and 2 tablets bid for the following three days 4.
- A study comparing Daflon 500 mg with a herbal preparation, Roidosanal, used a dosage of 500 mg, with the exact administration schedule not specified 5.
- A double-blind, placebo-controlled trial used a dosage of 2 tablets daily for two months 6.
Efficacy of Daflon in Treating Hemorrhoids
- Studies have shown that Daflon is effective in alleviating hemorrhoidal symptoms, including pain, heaviness, bleeding, pruritus, and anal discharge 2, 6, 3, 4.
- Daflon has also been shown to improve the proctoscopic appearance of hemorrhoids 2, 3.
- The efficacy of Daflon in treating hemorrhoids has been demonstrated in various studies, with significant improvements in symptoms and proctoscopic appearance compared to placebo or baseline values 2, 6, 3, 4.