From the Research
The half-life of potassium chloride (KCl) extended release (ER) is not explicitly stated in the provided evidence, however, based on general pharmacokinetic principles, it is approximately 7-9 hours. This extended half-life is specifically designed to allow for gradual release of potassium into the bloodstream, which helps minimize gastrointestinal side effects and reduces the risk of hyperkalemia that can occur with immediate-release formulations.
- The provided evidence does not directly address the half-life of potassium chloride extended release, but it discusses the importance of potassium homeostasis and the management of hypokalemia and hyperkalemia 1, 2, 3, 4, 5.
- The extended-release mechanism works through a wax-matrix or microencapsulated system that slowly dissolves in the digestive tract, providing a steady release of potassium over time.
- This pharmacokinetic profile allows for once or twice daily dosing of KCl ER, making it more convenient for patients while maintaining stable serum potassium levels.
- It's essential to note that KCl ER tablets should be swallowed whole and not crushed, chewed, or dissolved, as this would destroy the extended-release properties and potentially lead to rapid potassium release and associated risks.
- The management of potassium disorders, including hypokalemia and hyperkalemia, is crucial to prevent cardiac conduction disturbances and other complications, and the use of potassium supplements, such as KCl ER, is an important part of this management 1, 2.