From the Research
None of the listed immunoglobulins - Privigen, Flebogamma, Bivigam, and Gammaplex - are administered via subcutaneous injection. All four of these products are specifically formulated as intravenous immunoglobulin (IVIG) preparations, as indicated in their names. These medications are designed exclusively for intravenous administration and should never be given subcutaneously. The distinction between intravenous and subcutaneous immunoglobulin products is important because they have different formulations, concentrations, and stabilizers that make them appropriate only for their intended route of administration. Some key points to consider include:
- The formulation and concentration of IVIG products like Privigen, Flebogamma, Bivigam, and Gammaplex are not suitable for subcutaneous administration 1, 2, 3, 4.
- Subcutaneous immunoglobulin (SCIG) products, which are not included in this list, include medications such as Hizentra, Cuvitru, Xembify, and HyQvia, and are specifically designed for subcutaneous use 5.
- These SCIG products are designed with appropriate concentration and viscosity to be administered under the skin, typically into the abdomen, thighs, or upper arms, allowing for home administration by patients after proper training. It's also worth noting that the use of IVIG products via the incorrect route of administration can lead to adverse effects and reduced efficacy, highlighting the importance of adhering to the recommended administration route for each product 1, 2, 3, 4.