From the Guidelines
Ketosteril, which contains ketoanalogues of essential amino acids, helps manage chronic kidney disease by reducing nitrogen waste accumulation while providing essential amino acid precursors, and its use is recommended as part of a comprehensive CKD management plan, including dietary protein restriction and regular monitoring of kidney function, nutritional status, and electrolyte levels, as supported by recent studies 1.
Key Points
- Ketosteril is used to manage chronic kidney disease (CKD) by reducing nitrogen waste accumulation and providing essential amino acid precursors.
- The typical dosage is 1 tablet per 5 kg body weight daily, divided into three doses taken with meals.
- Ketosteril works by accepting nitrogen from the body to form essential amino acids, effectively reducing the workload on damaged kidneys while preventing protein malnutrition.
- This approach helps slow CKD progression, delay the need for dialysis, improve metabolic parameters, and reduce uremic symptoms.
Important Considerations
- Ketosteril should be used under medical supervision as part of a comprehensive CKD management plan.
- The plan should include dietary protein restriction and regular monitoring of kidney function, nutritional status, and electrolyte levels.
- Recent studies have highlighted the importance of individualized approaches to treating hypocalcemia and the potential harm associated with liberal calcium exposure in CKD patients 1.
Recommendations
- Use Ketosteril as part of a comprehensive CKD management plan, including dietary protein restriction and regular monitoring of kidney function, nutritional status, and electrolyte levels.
- Restrict the dose of calcium-based phosphate binders in adult patients with CKD G3a to G5D receiving phosphate-lowering treatment, as suggested by recent guidelines 1.
- Consider the potential harm associated with liberal calcium exposure in CKD patients and the importance of individualized approaches to treating hypocalcemia 1.
From the Research
Mechanism of Ketosteril in Managing Chronic Kidney Disease (CKD)
- Ketosteril, a preparation of keto-analogs of essential amino acids, helps in managing CKD by reducing the accumulation of nitrogen waste products in the body 2, 3, 4.
- It is used in combination with a low-protein diet to minimize the strain on the kidneys and slow down the progression of kidney disease 3, 5, 4.
Effects of Ketosteril on Kidney Function
- Studies have shown that Ketosteril can help reduce plasma urea and creatinine levels, indicating a decrease in nitrogen waste products in the body 2, 3, 4.
- It can also help improve glomerular filtration rate (GFR), a measure of kidney function, in patients with CKD 6, 5.
- Additionally, Ketosteril has been shown to reduce the risk of malnutrition and mineral metabolic disturbances in patients with CKD 6.
Clinical Benefits of Ketosteril
- Ketosteril has been found to be well-tolerated and effective in reducing the progression of kidney disease in patients with CKD 2, 3, 5, 4.
- It can help improve the nutritional status of patients with CKD and reduce the risk of complications such as uremic hyperparathyroidism 6.
- Overall, Ketosteril is a useful therapeutic approach in the management of CKD, particularly when used in combination with a low-protein diet 2, 3, 5, 4.