From the Research
It is not only safe but also potentially beneficial to take melatonin while on AREDS 2 supplements, as recent evidence suggests melatonin may reduce the risk of developing or progressing age-related macular degeneration. The AREDS 2 supplements, which contain vitamins C and E, lutein, zeaxanthin, zinc, and copper, are designed to slow the progression of age-related macular degeneration, while melatonin is a hormone that helps regulate sleep cycles and has been shown to have protective effects on the retina 1.
The most recent and highest quality study on this topic, published in 2024, found that melatonin use was associated with a reduced risk of developing AMD (RR, 0.42; 95% CI, 0.28-0.62) and progressing to exudative AMD (RR, 0.44; 95% CI, 0.34-0.56) 1. This study provides strong evidence for the potential benefits of melatonin in reducing the risk of AMD, and its findings are consistent with earlier studies that suggested melatonin may have protective effects on the retina 2.
While it is always advisable to consult with a healthcare provider before combining any supplements or medications, especially if you have underlying health conditions or are taking other medications, the current evidence suggests that melatonin and AREDS 2 supplements can be safely taken together. Key considerations include:
- Starting with a low dose of melatonin, as higher doses may not provide additional benefits and may increase the risk of side effects 3
- Monitoring for any potential interactions or side effects, although the current evidence suggests that melatonin and AREDS 2 supplements are unlikely to interact significantly
- Consulting with a healthcare provider to determine the best course of treatment for individual circumstances, as the benefits and risks of melatonin and AREDS 2 supplements may vary depending on individual factors such as age, health status, and other medications being taken.